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Roundabout homolog 4 is a protein that in humans is encoded by the ROBO4 gene.[1][2]


Further reading

  • Schmucker D (2003). "Downstream of guidance receptors: entering the baroque period of axon guidance signaling.". Neuron 40 (1): 4–6. doi:10.1016/S0896-6273(03)00603-2. PMID 14527427. 
  • Huminiecki L, Gorn M, Suchting S, et al. (2002). "Magic roundabout is a new member of the roundabout receptor family that is endothelial specific and expressed at sites of active angiogenesis.". Genomics 79 (4): 547–52. doi:10.1006/geno.2002.6745. PMID 11944987. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Park KW, Morrison CM, Sorensen LK, et al. (2003). "Robo4 is a vascular-specific receptor that inhibits endothelial migration.". Dev. Biol. 261 (1): 251–67. doi:10.1016/S0012-1606(03)00258-6. PMID 12941633. 
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Bedell VM, Yeo SY, Park KW, et al. (2005). "roundabout4 is essential for angiogenesis in vivo.". Proc. Natl. Acad. Sci. U.S.A. 102 (18): 6373–8. doi:10.1073/pnas.0408318102. PMID 15849270. 
  • Seth P, Lin Y, Hanai J, et al. (2005). "Magic roundabout, a tumor endothelial marker: expression and signaling.". Biochem. Biophys. Res. Commun. 332 (2): 533–41. doi:10.1016/j.bbrc.2005.03.250. PMID 15894287. 
  • Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMID 16335952. 
  • Gröne J, Doebler O, Loddenkemper C, et al. (2007). "Robo1/Robo4: differential expression of angiogenic markers in colorectal cancer.". Oncol. Rep. 15 (6): 1437–43. PMID 16685377. 
  • Okada Y, Yano K, Jin E, et al. (2007). "A three-kilobase fragment of the human Robo4 promoter directs cell type-specific expression in endothelium.". Circ. Res. 100 (12): 1712–22. doi:10.1161/01.RES.0000269779.10644.dc. PMID 17495228. 



Protein Robo4 may reverse macular degeneration, diabetic retinopathy




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